Discovery Of Insulin Essay

Discovery Of Insulin Essay-59
Banting served as a battalion medical officer in the Canadian Army Medical Corps; he returned to Toronto in 1919 after having been wounded in the arm by shrapnel.He trained as a surgeon at the Hospital of Sick Children in Toronto, then decided to open a small practice as a surgeon in London, Ontario.

Banting served as a battalion medical officer in the Canadian Army Medical Corps; he returned to Toronto in 1919 after having been wounded in the arm by shrapnel.He trained as a surgeon at the Hospital of Sick Children in Toronto, then decided to open a small practice as a surgeon in London, Ontario.

In 1921 researchers at the University of Toronto began a series of experiments that would ultimately lead to the isolation and commercial production of insulin—a pancreatic hormone essential for metabolizing carbohydrates—and the successful treatment of diabetes.

The connection between pancreatic secretions and diabetes was first shown in 1889 by two German physiologists at the University of Strasbourg, Oskar Minkowski and Joseph von Mering.

After 15 years at Western, Macleod accepted a professorship at the University of Toronto, where he conducted research on respiration.

Earlier in his career Macleod had published a series of papers on glycosuria, or the presence of sugar in the urine (a common indication of diabetes).

In the early 1920s Frederick Banting and Charles Best discovered insulin under the directorship of John Macleod at the University of Toronto.

With the help of James Collip insulin was purified, making it available for the successful treatment of diabetes.

Through the experimental efforts of these and many other researchers, the stage was set for the discovery of insulin—the hormonal antidiabetic secretion of the islets of Langerhans—in the first decades of the 20th century.

In 1920 Frederick Grant Banting (1891–1941) was a surgeon in a floundering practice in London, Ontario, Canada.

Banting and Macleod earned a Nobel Prize for their work in 1923.

At the turn of the 20th century a strict low-calorie, no-carbohydrate diet was the only effective treatment for diabetes.

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